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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Synthesis of N-formylnornuciferine with Cardiotonic Activity) ผู้เขียน: คมสัณห์ อิ่มพันธ์แบน,  ดร.งามผ่อง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ , Prasan Dhumma-upakorn, Rungnapa Mesripong, ดร.บุญส่ง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ สื่อสิ่งพิมพ์:pdf Abstract(-)-N-Formylnornuciferine (1), an aporphine alkaloid isolated from stems of Tinospora crispa (Borapet in Thai), showed in vitro cardiotonic activity. In an earlier study, it exhibited a significant increase in the force of contraction on the atria of an isolated rat heart with no significant change in the heart rate. As only very limited amounts of this active compound can be isolated from T. crispa, the evaluation of cardiotonic activity is hampered. One way to obtain sufficient quantities for pharmacological investigation is by chemical synthesis. In the current study, (?)-N-formylnornuciferine (1a) was successfully synthesized in six steps from homoveratrylamine with an overall yield of 50%. A palladiumcatalyzed coupling reaction was the key step in this synthesis. In the subsequent cardiotonic activity test, it was found that the racemic mixture, (?)-N-formylnornuciferine (1a), produced a reduction in the force of contraction and the heart rate, which was different from the activity of the natural aporphine alkoloid isolated from T. crispa. |
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